Summer Research Fellowship Programme of India's Science Academies

Analysis of chosen south Indian women to explore the predisposing factors that relates gut microbiome with PCOS: A case study

Anita Margret A

Assistant Professor, Department of Biotechnology, Bishop Heber College, Vayaloor Road, Tiruchirappalli, Tamil Nadu 620017

Dr. Joseph Selvin

Professor and Head, Department of Microbiology,Pondicherry University, R.V.Nagar, Kalapet,Puducherry 605014


Poly Cystic Ovarian Syndrome (PCOS) is an emerging health issue among the females and is considered as a threat in reproduction. The gut flora and the endocrine axis can retort to the indefinable biochemical disturbances that instigates PCOS. An altered gut microbiota can significantly correlate with PCOS .This proposal procures to detect the possible prevalence PCOS among south Indian women and access the association of predisposing factors that relates gut biome .The study is conducted using both electronic survey and through interview schedules using a set of predetermined questions .The data collected is dually based on descriptive and analytical methods with both primary and secondary sources of data. This research is segmented in to two phases where, the first, focused on college students aged (18-24 years) and second on sampling, among PCOS affected women from clinics. The initial part of the study constituted a total of 150 respondents whose responses was collected by circulating google forms that included a detailed questionnaire which associated the lifestyle and demographic status with the possible predisposable factors of gut biome. This study was performed to elucidate the prevalence of PCOS in a random manner among young community and relevant factors with gut microbiome. It signifies the relation of gut microbe with PCOS and hence the attributes related to its stimulation was assayed. Parameters such as awareness of probotics associated to its stimulating foods ,gastro intestinal health and antibiotic consumption were considered. Hence this survey instigated to find out the prevalence of PCOS among the college going young women and its association with their lifestyle diet and gut microbiome .Though the prevalence of the PCOS is only 8% among the respondents the study yielded interesting predisposing factors associated with the gut biome and probiotics with a good difference of significance.

Keywords: Poly Cystic Ovarian Syndrome, Endo crine axis, gut flora ,electronic survey, lifestyle diet, probiotics

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