Highly efficient click reactions catalyzed by polymer supported CuO nanoparticles under greener conditions
Main challenges of the 21st century demands scientific and technological attainments that must be followed under sustainable and environment-friendly approches. In this context, click reaction and green chemistry walk in hand to hand of a pathway of precise principles that helps to safeguard to the health of our planet against irresponsible and uncontrolled reactions. Click chemistry is the modular synthetic approach towards the assembly of new molecular entities. One of the click reaction is copper(I) –catalyzed azide-alkyne cycloaddition (CuAAC) leads to the formation of triazole products. CuAAC recognized as click reaction because of modularity, insensitive to the solvent parameter, wide in scope, high yielding, create only inoffensive byproducts, are stereospecific and regioselective. However, its application in industry is limited due to the use of toxic solvents and other issues like purification, removal of reagents etc. Hence, we intent to develop simple cheap non-toxic catalyst which can catalyze the reaction efficiently in green solvent such as only water and recyclable. In this context, we synthesize and characterize the water soluble catalyst comprising of modified cellulose polymer which supports the CuO nanoparticles. We further tested its efficiency against producing triazole product from various alkynes and azides.
Keywords: CuAAC reaction, green chemistry, copperoxide nanoparticles, homogenous catalysis, triazoles