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Summer Research Fellowship Programme of India's Science Academies

Genome-wide comparative analysis of human and chimpanzee protein sequences

M. Infanta Saleth Teresa Eden

B. Tech. Bioinformatics, Tamil Nadu Agricultural University, Coimbatore 641 003

Professor N. Srinivasan

Chairman, Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012

Abstract

Enzymes are proteins which drive functional processes in all forms of life. Though they are not required necessarily for the survival of any organism, they are indeed vital for its proper functioning. Comparative analysis of human and chimpanzee genome is important as the study involving genome-wide comparison would further narrow down to comparison of their proteome (the entire protein content found in an organism) by which the enzymes which are specifically found in both the species, human and chimpanzee, can be identified. Identification of such enzymatic proteins includes detection of orthologs between the two species. The specific enzymes which are obtained from human and chimpaanzee are further analysed for their enzymatic action which involves studying the reactions which they drive. the nature of those reactions, and the pathway in which they are involved.

Keywords: Enzymes, human, chimpanzee, comparative analysis, orthologs, species-specific proteins.

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