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Summer Research Fellowship Programme of India's Science Academies

ZEBRA FISH -MODEL FOR REGENERATION

VEDA RAKSHITHA A

GOVERNMENT DEGREE COLLEGE(A) 6025, SIDDIPET, TELANGANA,502103.

DR. NISHIGANDHA NAIK

DIRECTOR, HAFFKINE INSTITUTE FOR TRAINING, RESEARCH AND TESTING, MUMBAI.

Abstract

Zebra fish is an emerging model for studying human diseases. Sequencing of the entire genome of zebra fish revealed that 70% of its protein coding genes are related to genes found in humans and 84% of genes known to be associated with human diseases have a zebra fish counterpart. Zebra fish provides some clear advantages over other animal models. It is a quick, user friendly, transparent, robust and economic option. The present project aims at studying the effect of chemical stress (ethanol and Ayurvedic formulations – NSB001 and badampak) on the regenerative capacity of zebra fish. Our studies show that ethanol treatment results in toxicity, but does not affect regeneration potential. Treatment with NSB001 and badampak stimulates regeneration, but neutralization of ethanol toxicity and induction of regeneration is seen only after NSB001 treatment, irrespective of time of treatment initiation. This suggests that the induction of regeneration by NSB001 and badampak could be by different pathways. Therefore NSB001 and badampak help in regeneration and ethnol results in toxicity.

Keywords: zebrafish, Ayurvedic formulations, Regeneration.

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