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Summer Research Fellowship Programme of India's Science Academies

TERATOGENIC STUDY OF LYSOZYME TEMPLATED SILVER-PLATINUM NANOCOMPOSITE IN CHICK EMBRYONIC MODEL

Pingal Pritam

Department of Molecular Biology and Biotechnology, Cotton College, Pan Bazar, Guwahati-781001

Dr. Chittaranjan Patra

Principal Scientist, Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, Telangana, India-500007

ABSTRACT

With the rapid advancement in medical sciences, nanomaterials have emerged as the new front for combating diseases. Nanocomposites are multiphase solid materials where one of the phases has one, two or three dimensions less than 100 nm. As these materials are now being used for treatment and detection of diseases, proper studies are required on their toxic effects. Teratogenicity refers to the disruptions in the normal embryonic development, which may halt pregnancy or cause congenital malformations. A teratology screening system would detect agents hazardous to the conceptus before they can perturb embryonic development in humans.  Lysozyme templated Ag@Pt nanocomposites have been found to show anti-cancer effects. However, it is necessary to study the toxicity effects of any nanomaterial prior to its further application in in vivo system. In this project, we have studied the teratogenic effect of lysozyme templated Ag@Pt NCs by taking the chick embryonic model.

Keywords: Nanomedicine, Teratogenicity, Ag@Pt nanocomposites, lysozyme, chick embryo model

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