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Summer Research Fellowship Programme of India's Science Academies

Understanding the significance of INTERLEUKIN-1 Variants in Population and Disease

BANDI. NEHA REDDY

KAKATIYA UNIVERSITY, WARANGAL 506003.

DR. MOINAK BANERJEE

SCIENTIST(F), HUMAN MOLECULAR GENETICS, RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY, DBT, THIRUVANANTHAPURAM 695 014.

Abstract

Interleukins are a group of cytokines which aid cell to cell communication and affect all types of cells. These immuno-modulating agents are classified into 38 interleukins based on their function. IL-1 has both pro- and anti- inflammatory effect which is further sub- divided into a family of 11 cytokines. Among these IL-1α, IL-1β, IL-1Ra are the most studied. SNP is a single nucleotide polymorphism i.e. a variation of a single nucleotide in a sequence. They vary from person to person and thus can act as genetic markers by which predisposition risk for a large number of diseases ranging from sensory diseases to chronic illness like cancer or even neurodegenerative diseases in a population can be traced. For this study IL-1β which is highly polymorphic was chosen and the SNPs were screened based on selection criteria such as minor allele frequency, tagging status and functional score. Based on these criteria rs1143634 and rs1143627 were chosen for the study. We screened these SNPs by Sanger sequencing. The results obtained after the analysis of Kerala population were compared with world population frequencies and the similarities shown by Kerala population were graphically represented. Further, the diseases associated with these two SNPs with the risk allele were assessed in different populations. This genomics information could be used for predicting the prevalence of a disease in a given population.

Keywords: Interleukins, IL-1β, SNP, Population, Disease.

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