Summer Research Fellowship Programme of India's Science Academies

Synthesis of MCM-48 (Mobil Composition of Matter No. 48) by modified stober method and study of the effect of molar concentration of CTAB, TEOS, and PF127 on the size and surface Zeta potential of MCM-48.

Aqib Javaid

Sharda University, Greater Noida, UP

Dr Prabhat. R Mishra

Principal Scientist, CSIR Central Drug Research Institute, Lucknow 226031


A rapid and simplistic synthesis procedure for spherical MCM-48 mesoporous silica nanoparticles (MSN) is based on the modified Stober method. The size of MCM-48-type MSNs can be controlled by the stirring rate and molar ratios of silica source, H2O, and a surfactant such as CTAB, PF127 etc. In this paper, the formation of colloidal spherical MCM-48-type MSNs is obtained using CTAB as a template, TEOS as a silica precursor, NH4OH as catalyst, H2O and ETOH as dispersion media (Solvent), and triblock copolymer Pluronic F127 as the main component for determining the particle size. We have used Zetasizer for the determination of size, PDI and zeta potential of MSNs. Based on our experiment, the average size of monodisperse spherical MSN was found to be in the range of 103nm-453n. Moreover, the size of MSNs can be precisely controlled by varying the molar concentrations of PF127, and TEOS and PDI can be controlled by varying the molar concentration of CTAB. In order to study the individual and combined effect of CTAB, PF127, and TEOS on the size, PDI and zeta potential of the particles, and 2-level full factorial design with three controllable factors, have been used. Thus a total of 8 (2^3) experiments were performed. The present study of the synthesis conditions and the binary surfactant system in MCM-48 synthesis offers reproducible and facile synthesis of the monodisperse spherical MCM-48 mesoporous silica nanoparticles with precise size, PDI and zeta potential control, and thus has vast prospects for future applications for drug and gene delivery.

Keywords: Mesoporous, nanoparticlas, Surfactant, drug delivery

Written, reviewed, revised, proofed and published with