Summer Research Fellowship Programme of India's Science Academies

Investigation on Antimicrobial Activity of Temporin as Peptides

Soumya Ranjan Pujahari

University of Hyderabad, Hyderabad 500046

Dr. K. Muruga Poopathi Raja

Department of Physical Chemistry, Madurai Kamaraj University, Madurai 625021


Peptides have a great potential in applications such as hormone therapy, in controlling many physiological reactions in organisms, in drug delivery systems, as an antimicrobial agent, an anti cancer agent etc. Peptides that are lethal to microbes are called the antimicrobial peptides. Peptides can attach to the cell membranes of microbes following cell disruption or they can penetrate the cell membrane and damage the intracellular components of the cell. Membrane-active peptides are of particular interest, since they do not easily induce microbial resistance. Temporin is a class of antimicrobial peptide naturally found in Rana remporaria. The 13 residues natural peptide is classified as several types such as temporin A,B,C,D,E,F,G,H,K,L and they have different potential applications. Here a Temporin class B peptide is modified to give it greater potential application than the naturally found Temporin.

Keywords: temporin, solid phase peptide synthesis

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