Spectral Study on Curcumin and Synthesis of Gluocosyl-Curcumin Derivative for Targeted Photocytotoxicity
Curcumin, an active ingredient of turmeric (Curcuma longa), was first isolated by Vogel and Pelletier in 1815 from the rhizomes of turmeric. Curcumin [(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] consists of three functional reactive groups: two o-methoxyphenolic groups linked through an α,β –unsaturated β-diketone moiety. The later participates in keto-enol tautomerism and the enolic form is reported to be more stable in organic solvents than the keto form. Curcumin has been used as a dietary spice and in treating various health issues for thousands of years in many Asian countries. However, research has only relatively recently established the chemopreventive and therapeutic potential of curcumin.